Understanding the dynamics of wind-driven natural ventilation is essential for developing effective strategies to enhance indoor environmental quality and reduce energy consumption in buildings. The natural ventilation in buildings is influenced by multiple factors, making the study of wind-driven natural ventilation complicated. This work investigates the influence of roof pitch angle on natural ventilation effectiveness in pitched roof buildings. Computational fluid dynamics simulations were performed on building models with roof pitch angles of 16.6°, 26.5°, and 36.8°, incorporating various diagonally located opening configurations. Ventilation efficiency was assessed using indoor air distribution and indoor air quality metrics, including normalized mean velocity (NMV), velocity homogeneity index (H), and air change per hour (ACPH). The highest values of NMV, H, and ACPH were obtained with a lower roof pitch angle of 16.6°. However, for NMV and H, the windward opening was located at the bottom, while the leeward opening was at the top. In contrast, for ACPH, the windward opening was situated in the middle, and the leeward opening was at the bottom. The findings demonstrated that the natural ventilation efficiency is strongly linked to both the roof pitch angle and the opening configurations. The outcomes of this study would be useful for planning and designing a sustainable built environment.