The marine animals trade is a serious concern throughout the World and the trade of marine species such as corals, turtles and seahorses, has a significant impact on ecological system, economic, and conservation initiatives. The frequent poaching of seahorses for its use in traditional medicine, decorative purposes and the aquarium industry through the World. The excessive commercial and ornamental traffic of coral leads to reef degradation and decline marine biodiversity of corals and its dependent species. Sea turtles are also categorized in endangered species due to excessive poaching for their eggs, meat, and shells. One international agreement that attempts to limit and control overexploitation is the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) is addressed the marine issues. Nevertheless, issues including ongoing illegal trade, weak enforcement, and the destruction of natural regions persist despite the efforts of CITES. To deal with issues, requires a combined project of locally driven, implementation of successful conservation tactics, and sustainable trading practices to oversee the survival of these species. In the regard, this chapter explores the effects of the trade in marine species, assesses the work of the current conservation measures, and discussed about adequate ways to decrease its detrimental effects.