Breast cancer, as the most commonly diagnosed cancer among women, has a profound psychological and emotional impact across all stages of the disease trajectory. This chapter explores the psychosocial spectrum of breast cancer care, with an emphasis on the psychological implications of diagnosis, the emotional challenges during treatment, and mental health concerns in the post-treatment phase. It examines the influence of social, interpersonal, cultural, economic, and spiritual factors on mental health outcomes. Evidence-based approaches from psychosocial screening to effective interventions and support strategies are also discussed. Additionally, the role of multidisciplinary teams in delivering holistic, patient-centred care is highlighted. Addressing these dimensions can help improve the overall quality of life and support recovery and resilience in individuals affected by breast cancer.