Developing human-controllable artificial intelligence (AI) and achieving “meaningful human control” (MHC) has become a vital principle to address these challenges, ensuring ethical alignment and effective governance in AI. MHC is also a critical focus in human-centered AI (HCAI) research and application. This chapter systematically examines MHC in AI, articulating its foundational principles and future trajectory. MHC is not simply the right to operate, but the unity of human understanding, intervention, and the traceability of responsibility in AI decision-making, which requires technological design, AI governance, and humans to play a role together. The value orientation of MHC ensures AI autonomy serves human needs without constraining technological progress. The mode of human control needs to match the levels of technology, and human supervision should balance the trust and doubt of AI. For future AI systems, MHC mandates “human controllability as a prerequisite,” requiring: (1) technical architectures with embedded mechanisms for human control; (2) human-AI interactions optimized for better access to human understanding; and (3) the evolution of AI systems harmonizing intelligence and human controllability. Governance must prioritize human-centered AI strategies: policies balancing innovation and risk mitigation, human-centered participatory frameworks transcending technical elite dominance, and global promotion of MHC as a universal governance paradigm to safeguard human-centered AI development. Looking ahead, there is a need to strengthen interdisciplinary research on the controllability of AI-driven autonomous systems, enhance the ethical and legal awareness among stakeholders, moving beyond simplistic technology design perspectives, and focus on the knowledge construction, complexity interpretation, and influencing factors surrounding human control. By fostering this transition in MHC, the development of human-controllable AI can be further advanced, delivering human-centered AI systems.