Efficiency improvements in drive technology can significantly contribute to reducing CO2 emissions and achieving global climate protection goals. These improvements can be realized by further development and optimization of existing machine elements, as well as by considering new concepts. High reduction hypoids represent a novel transmission concept that allows high transmission ratios in a single gear stage, offering an alternative to widely used high reduction worm gears. Some publications have postulated significant efficiency advantages of high reduction hypoids compared to assimilable high reduction worm gears. Additionally, the steel-steel contact in high reduction hypoids eliminates the need for bronze alloys, which are commonly used in worm gears. This can lead to potential cost reductions, especially considering the recent increase in copper prices. However, the potential efficiency advantages and the operational behavior of high reduction hypoids in a power range comparable to worm gears have not yet been scientifically investigated. In this paper, experimental investigations on the efficiency of high reduction hypoids are shown. The results will be compared with those of the reference worm gear according to DIN 3996:2019 [1] on the level of the overall gearbox losses. The experimental results show similar efficiency values for the total gearbox between HRH and worm gears above \(\eta_{total} = 85\%\) for comparable operational conditions. In a concluding summary, the discussion of possible influencing parameters and an outlook on further investigations regarding high reduction hypoids are given.