The potential health benefits of functional foods or nutraceuticals for human health are suggested by ample evidences, collected over the years. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with numerous health advantages, has sparked increased interest among fitness-oriented individuals, scientists, and the pharmaceutical industry. Nigella sativa is an annual herb with many therapeutic applications in addition to its commercial value as a plant that yields spices. It has long been a part of the folk medicine systems of Europe, the Far East Asia, and the Arabian Gulf region. Since ancient times, seeds and oils of N. sativa have been the main medicinal source for masses. It is one of the most widely used herbal remedies in the world and contains a variety of chemical components, including alpha-hederin, nigellicine, carvacrol, nigllimine, nigellidine, thymoquinone, dithymoquinone, and thymol. Its principal bioactive component, thymoquinone (TQ), has been shown to have pleiotropic pharmacological activities, including the ability to reduce oxidative stress and inflammation, as well as to boost immunity, cell survival, and energy metabolism, all of which contribute to a variety of health advantages such as protection against metabolic, cardiovascular, digestive, hepatic, renal, pulmonary, reproductive, and neurological illnesses, cancer, and so on. This study provides a brief explanation of the phytochemicals, pharmacological characteristics, Ayurvedic properties, and traditional uses of Nigella sativa.