In Zimbabwe, parenting orphaned and vulnerable children (OVC) in the twenty-first century is a pressing concern, exacerbated by the country’s history of economic challenges, the HIV/AIDS pandemic, and cultural shifts. Caregivers of OVC face numerous challenges, including limited access to resources, social stigma, and the erosion of traditional support systems. This book chapter explores the challenges of parenting OVC in Zimbabwe from an indigenous knowledge perspective, using a desktop and discourse analysis approach. This chapter examines the role of Indigenous knowledge and traditional practices in supporting caregivers and promoting resilience among OVC. The analysis underscores the significance of cultural context in shaping parenting practices and emphasises the necessity for culturally responsive support systems. The main finding of this chapter is that Indigenous knowledge and traditional practices are critical in promoting the well-being of OVC but are often marginalised in modern parenting practices. This chapter recommends that policymakers and practitioners prioritise the integration of Indigenous knowledge and traditional practices into parenting programs and services for OVC in Zimbabwe, to promote more effective and culturally responsive support for caregivers and OVC.