External diseases and eyelid pathologies comprises of various conditions affecting the eyelids, conjunctiva and tear films. Eyelid conditions such as squamous blepharitis, hordeolum, chalazion, dry eye and allergic conjunctivitis seldom requires histopathological diagnosis. Various pathological entities such as epidermal or epidermoid cyst, inverted follicular keratosis, keratinous cyst, different other cysts in the glands of the eyelids may require surgical excision. Malignant eyelid tumors such as basal cell carcinoma, sebaceous gland carcinoma, squamous cell carcinoma and melanoma etc. are diagnosed in ocular pathology laboratory. Frozen section, map biopsy and histopathology are the cornerstone of diagnosis in eyelid malignancies.