The Main Feedwater Isolation Valve of the HPR holds a crucial position in ensuring swift isolation in the case of a rupture accident occurring in the primary feedwater pipeline. Taking into account parameters such as temperature, pressure, flow rate, and environmental conditions of the HPR process system, the valve is ultimately designed as a gate valve which consists of a pressure-retaining body, a valve disc, and an actuator. This paper conducts a thorough analysis of the technical challenges encountered during the design of the Main Feedwater Isolation Valve for the HPR and undertakes design selection and optimization based on the characteristics of the process fluid system. An equipment qualification plan was formulated and implemented in accordance with the operating and accident conditions to ensure compliance with design requirements. By identifying the key challenges in the design and research process, valuable technical experience has been accumulated, thereby enhancing independent design capabilities. This contributes to promoting the development of nuclear equipment and supporting the clean, efficient, and sustainable growth of the nuclear energy sector.