The uranium- and nitrate-containing wastewater, produced during the process of uranium purification and conversion which adopting wet denitrification technology route, is still radioactive after extracting and recycling most of uranium. Therefore, it needs to be further recovered to reduce the uranium content in the external drainage. However, due to the high salt content in this part of wastewater, it is easy to cause blockage of subsequent membrane treatment elements, and affect the operation of deep recovery of uranium. And it is urgent to carry out desalting treatment. Spray drying is traditionally used, which consumes enormous energy. As one of the common desalination methods, evaporation has two mainly energy-efficient methods, multi-effect evaporation (MEE) process and mechanical steam recompression (MVR) process. MEE process system is complicated, and difficult to use the ineffective steam, which will result in energy waste. Although the MVR process can fully recover the heat of secondary steam, it is only suitable for balanced discharge systems, and cannot be used when the concentration is high. Based on this, this paper creatively puts forward the “MVR coupling single effect” evaporation and concentration process to reduce the energy consumption. At the same time, nitrate, the main salt impurity in wastewater, can be removed by “thickening-centrifugation” according to the different solubility of uranyl nitrate. The process can achieve the desalination of wastewater under low energy consumption, meet the requirements of further deep purification, and provide a new idea for the treatment of low radioactivity and high salt wastewater.