The currently released standards do not specify the methods to be used to analyze the fire resistance performance of steel plate concrete modules. However, when steel plate concrete modules are used as internal structures in reactor buildings, they may face the risk of leakage of lubricating oil in reactor cooling pump and fire, it is necessary to analyze the possible impact of the fire on the structure. International Standard ISO834 is commonly used to describe the steel structure temperature time curve induced by a fire when performing thermal–mechanical coupled analysis of steel structures. However, lube oil fire can grow more rapidly but short than that ISO834 describes. This paper demonstrated a fire-thermal-structural coupled analysis based on FDS and ABAQUS, which was used to simulate the steel plate concrete module’s thermal response under pump lube oil fire in reactor building of nuclear power plants according to the calculated adiabatic surface temperature obtained by FDS. The temporal and spatially varying AST results are imported from the FDS into ABAQUS models. Meanwhile the mechanical performance of the overall structure under fire is numerically analyzed by using ABAQUS. The results of case study demonstrated that the section-average temperature only increases by 27 °C. This generates a predicted 10% permanent reduction in wall stiffness locally at the pump room and a permanent 2% reduction in wall strength.