An integral part of plant development, growth, and stress tolerance is a process that involves the interplay between nutritional dynamics and the homeostasis of reactive oxygen species (ROS). This chapter describes how crucial the relationship of nutrient availability concerning ROS balance could be with respect to nutrient deficiency or excess, causing oxidative stress and how oxidative stress influences nutrient uptake and signaling pathways. The interplay of macronutrients, including nitrogen, phosphorus, potassium, sulfur, iron, zinc, manganese, as well as other similar major and minor elements, with ROS metabolism, synergistic, and antagonistic with one another, and is focused on maintaining cellular redox homeostasis. Excessive reactive oxygen species generation and oxidative damage to proteins, lipids, and nucleic acids are common outcomes of dietary deficits, especially macronutrient shortages. In plants, nutrient-ROS interactions are complicated, and ROS’s dual role as harmful agents and signaling molecules reflects that. It is now much more important to modify nutrition to prevent ROS damage when subjected to abiotic conditions like drought, salt, and high temperature. Nutrient supplementation and priming strategies for increasing stress tolerance through ROS modulation were explored. This has also highlighted genetic engineering approaches through the manipulation of antioxidant genes and nutrient transporters as promising avenues in the development of stress-resilient crops. Roles of beneficial microorganisms were also noted in improving nutrient availability and ROS balance, which can be enhanced in the future towards sustainable agriculture.