Both internal and external variables influence plant development and growth. One of the limiting parameters that determines crop productivity is temperature. The function of intrinsic components, such as phytohormones and signaling molecules, strengthens plant defense responses in high-temperature environments, increasing plant survival rates. Recent studies suggest that isoprenoid derivative molecules regulate resilience responses, which explains why plants develop with such fantastic plasticity. Gibberellins (GA), abscisic acid (ABA), cytokinins (CK), strigolactones (SLs), and brassinosteroids (BR) are isoprenoid derivative signaling molecules crucial in thermotolerance responses. Although the exact mechanism of action is still unknown, mineral nutrients may be essential in stimulating the signaling cascade, or these signaling molecules may enhance nutrient absorption, leading to thermal tolerance. This chapter focuses on the interaction between isoprenoid derivative signaling molecules and mineral nutrients in heat stress conditions.