Significant challenges to plant survival and production are being brought about by the phenomena of climate change. Heavy metals, high heat or cold, drought, or salt can have a significant impact on plant growth indices. Redox signaling, mediated by antioxidants and reactive oxygen species (ROS), plays a crucial role in controling how plants adapt to environmental challenges. Many metabolic reactions produce reactive oxygen species (ROS), which include superoxide, hydrogen peroxide, and hydroxyl radicals. In addition to causing oxidative damage when present in excess, reactive oxygen species (ROS) act as signaling molecules that set in motion a complex cascade of reactions. Redox homeostasis and cellular oxidative stress mitigation are mostly accomplished by antioxidants such ascorbate, glutathione, and a variety of enzymes generated inside plants. In this chapter, we will look at how antioxidants and reactive oxygen species (ROS) work together to keep redox homeostasis in check. Furthermore, the chapter explores the possibility of modifying redox signaling pathways to increase climatic stress tolerance in plants.