MEMEs are widely used on the internet and often carry strong elements of sarcasm or irony. Understanding their hidden meanings typically requires a joint interpretation of text and vision. Existing methods focus on the dual-stream vision-language model to extract the visual and text simultaneously, which lacks background information and prior knowledge about the comprehensive explanation of MEME. One feasible option is to adopt chain-of-thought (CoT). However, the simple CoT approach lacks multi-perspective thinking, which may compromise the reliability of the resulting answers. Moreover, it often relies on shallow feature fusion, lacking the fusion of local details and fine-grained visual-prompt text alignment. This limitation prevents a deeper understanding of the intricate connections between the visual and the text. Herein, an enhanced vision-language multi-CoT (EVL-MCoT) approach is proposed to address these limitations. By promoting multi-CoT, EVL-MCoT enhances consistency and reduces bias in the decision-making process. Additionally, we design a prototype-guided and context-guided decoding framework, which incorporates visual prototypes to guide the fusion process and enables the model to align textual and visual information more precisely. We achieve promising results on the HatefulMemes and MultiOff datasets. The source code has been publicly released and is available at https://github.com/BGWH123/EVL-MCoT .