Atmospheric dispersion conditions and population distribution are the key emergency factors that distinguish inland sites from coastal sites. In this paper, data from the meteorological observatories around the some inland sites, global reanalysis data of ERA5 was collected. Two models, plume model and puff model, were used to estimate the atmospheric dispersion factor (X/Q) of some inland sites. Based on the postulated siting accident source term of HPR 1000 (Hua-long Pressurized Reactor), its suitability at inland site was analyzed. The demographic factors of an inland plant site of China were analyzed using site population and atmospheric dispersion. The results of the study showed that the HPR 1000 could be adapted to sites with more unfavorable dispersion conditions. Taking into account the actual atmospheric dispersion characteristics of the plant site, the areas that need to be focused in the emergency response are shifted from the original actual densely populated areas to areas with a higher demographic factor (ESE~S), which has important guidance for the formulation of inland nuclear emergency response plans.