Morphing wing can adjust the aerodynamic shape according to the flight conditions and tasks, which plays an important role in improving aerodynamic efficiency, reducing noise and realizing laminar flow. As an important application scenario of morphing wing, variable camber leading edge has been widely concerned by international scholars. However variable camber leading edge needs to meet the requirements of large camber changes and high aerodynamic loads. At present, the rigid-flexible coupling structure is the most effective way to achieve this goal, but the deforming accuracy, deforming ability of compliant skin and the complexity of driving mechanism are still the difficulties in the design of the rigid-flexible-coupling variable camber leading edge. In this paper, the structural design methods of rigid-flexible-coupling variable camber leading edge based on open-chain mechanism and closed-chain mechanism are proposed respectively, and the final physical mock-ups are verified and the brief comparison is made. The results show that the variable camber leading edge of the open-chain mechanism and the closed-chain mechanism have advantages and disadvantages in different aspects such as the weight, deformation capacity, deformation accuracy and reliability. Therefore, all these factors should be comprehensively compared on the basis of detailed design to determine which scheme is more suitable for future engineering applications.