In this paper, T800 carbon fiber reinforced composite materials are selected to carry out a comparative study on quasi-static indentation damage and residual strength under different support methods. Referring to the standard ASTM D6264, two support methods, square hole and round hole, were used to carry out quasi-static indentation test, and the residual strength test was carried out on the sample that met the target pit depth. The differences of different boundary conditions on the quasi-static indentation damage of composites were analyzed from four aspects: damage area, loading curve, residual strength and damage evolution. During the test, the damage form and damage evolution information were obtained with the help of pit meter, ultrasonic C-scan, and acoustic emission acquisition system. The results show that under the same target pit depth, the damage area under the support of the square hole is small, and the maximum load is also small. However, in the case of a small damage area, the residual strength of the square hole support is smaller than that of the round hole support, and it is found that the acoustic emission detection is caused by the large accumulation of internal damage energy under the support of the square hole.