This paper focus on the research object of co-curing sandwich structure door with hybrid core materials. A mesoscopic simulation model for resin-based composite honeycomb sandwich structures was established, and the top and bottom surfaces of honeycomb were pre-cured to apply fixed constraints to effectively avoid defects such as slippage and collapse at the chamfer after analyzing. An adjustable mold based on multi-point forming theory was designed and a dynamic real-time tracking device was developed to monitor the deformation of the adjustable mold. Based on macroscopic curing simulation analysis results of resin-based composite sandwich structures, a complete set of deformation control methods for composites were achieved through simulation analysis of curing-induced deformation and compensation adjustment of mold surfaces. These methods were applied to quality optimization in high curvature and ultra-thick core sandwich structures, providing critical support for the application of such high curvature and ultra-thick sandwich structural components on aircraft.