Aiming at the problem of the long computation time of computational fluid dynamics in the traditional aerodynamic-structural coupling optimization process, the research on the aerodynamic force calculation technology based on the high-order panel method and the aerodynamic force interpolation algorithm based on the minimum strain energy principle was carried out. A structural size optimization algorithm combining the criterion method and the programming method was designed, and the algorithm for updating the spatial coordinates of the aerodynamic calculation grid based on the radial basis function was studied. An aerodynamic-structural coupling optimization process was constructed, and based on the open-architecture of the domestic structural analysis software SABRE, an aerodynamic-structural coupling optimization software was developed. Finally, the aerodynamic force calculation model and the structural finite element model of a typical wing were established, and the aerodynamic-structural coupling optimization was carried out. The weight of the wing structure was reduced by about 5.1%, indicating that this software can provide support for the design of such structures.