This paper investigates the strategies and analysis of one-step multi-pursuer Orbital Pursuit-Evasion Games (OPEGs) under Kepler dynamics. Specifically, we establish the pursuers’ strategy by considering all possible evader options and optimizing the target allocation to minimize the pursuers’ mass. Our findings reveal that a collaborative effort of two less capable pursuers can successfully intercept a more maneuverable evader. However, we also show that the mass or cost required for multi-pursuer OPEG is higher than that for traditional single-pursuer OPEG when intercepting the same evader. Furthermore, we quantify the \(\Delta V\) required for one pursuer to accomplish the interception mission typically assigned to two pursuers. Our results suggest that using multiple pursuers for interception missions may not be economical with current space technology. Instead, enhancing the ability of a single pursuer emerges as a more efficient approach, particularly when considering the limited mobility of the evader. Lastly, we discuss the limitations of current cost functions, the introduction of deterrence through additional pursuers, and marginal effects within OPEGs, providing ideas for future research on OPEGs.