This article addresses the challenges posed by the large quantity of equipment installations and the substantial volume of electromechanical items in nuclear power station construction. Based on the design of a specific nuclear power plant, digital technologies are employed to filter and categorize equipment and rooms, thus establishing a method for selecting key equipment and critical rooms. The article proposes a method for conducting construction simulations during the design phase, centered on the selected key equipment and rooms. Dynamic simulation techniques are utilized to validate the transportation and installation process of equipment as well as the logical sequence of room installation. This also includes the feasibility verification of advanced construction techniques, such as modular construction and on-site automated welding. Through an analysis of actual case studies, the article demonstrates how the methods described contribute to mitigating construction risks, optimizing design and construction plans, and lay a foundation for the design of construction schedules and further optimization in nuclear power plant construction.