Nuclear-powered spacecraft, using self-sustained nuclear fission energy, can carry out more complex and prolonged deep space exploration missions, providing strong support for future resource exploitation. Space nuclear reactor power supply, with the characteristics of high energy density and non dependence on the sun, is regarded as an ideal choice for future space power supply. This paper firstly introduces the structure and working principle of space nuclear reactor power supply, followed by the development of autonomous control research paradigm of space reactor power supply, and then utilizes the feature-based multi-source information autonomous control analysis method to adapt the development of space reactor power supply, and finally looks forward to the development prospect of future nuclear-powered space-craft, and puts forward suggestions for technological breakthroughs.