Weather conditions have a big influence on ambient air pollution because they affect air pollution emissions, transportation, manufacturing, and deposition. The present investigation examined the correlations between climatic characteristics and ambient air pollution concentrations in the East Khasi Hill district of Meghalaya. For a continuous 12-month period from January 2023 to December 2023, a methodical study of temperature, relative humidity (RH), and air pollutant, PM2.5, was conducted. There were noticeable seasonal trends for PM2.5, with the peak levels happening before the monsoon and the trough levels throughout the rainy season. Looking at how air pollutants and climatic variables are connected in Shillong. For all three seasons, the correlative analysis demonstrates a negative link between PM2.5 and temperature; however, in the post-monsoon period, a positive correlation is shown between PM2.5 and relative humidity. According to these results, weather conditions play a big part in contributing to air pollution, which shows significant fluctuations across various geological regions and seasons. Under different weather conditions, these findings may improve the precision of air pollution predictions, increase comprehension of the mechanisms that generate air pollution, and propose effective strategies for pollution mitigation.