Contamination with heavy metals and trace elements has been a growing source of concern worldwide. Since the Industrial Revolution, natural and human activities have resulted in an increase in the release of toxic metals and metalloids into the environment, including cadmium, mercury, arsenic, chromium, nickel, copper, lead, zinc, and others. The health of people is seriously endangered by these toxins. Phytoremediation is a commonly used, affordable, and sustainable alternative to conventional procedures for cleaning up soils polluted with metals and metalloids. This chapter deals with the advantages and challenges of phytoremediation especially on phytostabilizations as well as handling requirements, correct disposal, and management of byproducts produced during phytoremediation operations. In the area of phytoremediation, phytoextraction, which employs hyperaccumulator plants to permanently remove heavy metals and metalloids from soils, has turned out to be the most successful technique. There are already more than 400 hyperaccumulator plants known to be capable of collecting different heavy metals and metalloids from soils all over the globe.