This research examines the failure behavior of API-5LX-42 mild steel pipes, which have a wall thickness of 9.5 mm and an outer diameter of 324 mm, under extreme loading conditions such as internal blasts. The simulations employed in this study integrate the strength model and have shown strong alignment with experimental data, thus confirming the model’s reliability. The objective of this research is to produce validated data that will contribute to the development of failure criteria and models. These tools are anticipated to enhance design codes for containment vessels of a similar nature. The research underscores the critical importance of precisely defining material behavior, particularly under conditions of high-rate loading, and accurately characterizing the conditions under which explosives are loaded. This investigation aims to deepen the understanding of how steel pipes respond dynamically to explosive forces. The insights gained have significant implications for the design and safety of containment vessels that face similar explosive environments. Through this work, there is potential to significantly enhance the structural integrity and operational safety of vessels used in industries where explosive risks are a concern.