Aging is associated with a gradual decline in metabolism, leading to the prevalence of metabolic diseases such as osteoporosis and obesity. The relationship between metabolic diseases and aging is closely linked to the dysfunction of various signaling molecules in the body. NO, a critical signaling molecule, is essential for glucose, lipid, and energy metabolism and also contributes to aging protection. Nitrate-nitrite serves as a significant means of maintaining NO levels in the body. Our findings indicate that exogenous nitrate supplementation can effectively prevent osteoporosis and obesity, slow the aging process, and play a crucial role in preventing metabolic diseases associated with aging.