The world's first industrial nuclear energy steam supply project implemented in Chinese commercial nuclear power unit. Based on the analysis of the influence of main parameters after cogeneration, the thesis put forward the operation control measures, aiming at controlling main steam flow, main condensate flow and main steam pressure parameters. According to the steam energy supply system process, the new operating conditions after combining heat and power generation are sorted out, including normal operating conditions, abnormal operating conditions and transient operating conditions. On this basis, combined with the power change adjustment test results of the original comprehensive test project of VVER nuclear power unit, considering the operating conditions of the unit after cogeneration, the new comprehensive test items and test contents are set up, which can provide a reference for the comprehensive test setting of the steam energy supply transformation nuclear power unit or the new nuclear heating unit.