Under the nuclear power EPC general contracting model, several project departments have encountered challenges in effectively managing and supervising measuring instruments utilized by contractors for civil construction, installation and commissioning of nuclear engineering projects. These challenges are exacerbated by inadequate management methods and tools. This paper addresses the recurring issue of substandard quality in measuring instruments by quantifying associated risks. Through classification management method, it classifies and classifies according to the degree of impact of measuring instruments applied to nuclear engineering sites or equipment on quality and safety. The risk matrix assessment method is utilized to quantitatively manage the life-cycle risks associated with measurement instruments at construction sites. A risk monitoring matrix model is established to conduct comprehensive risk assessments of these instruments. This process enables supervision and provides recommendations for subcontractors’ instruments, ensuring them remain available, controllable and measurable in nuclear engineering. This approach significantly enhances the timeliness, accuracy and authenticity of engineering quality data. Subsequently, the establishment of an integrated management system for nuclear power measuring instrument information risk would be considered, incorporating a qualified supplier base, instrument management information and verification functions for calibration certificates. It can achieve comprehensive life-cycle risk management for measuring instruments, enabling timely responses to risks based on risk alerts. This enhances management efficiency, reduces management costs, elevates the management standards of measuring instruments, and ensures the quality and safety of nuclear power construction.