Alcohol is one of the most common causes of chronic liver disease and cirrhosis of the liver throughout the world. This chapter highlights the major points about epidemiology, natural history, risk factors, clinical features, diagnosis, and treatment of alcohol-related liver disease (ALD) with an emphasis on liver transplantation (LT). The spectrum of disease of ALD is varied. Patients can present with an asymptomatic rise in transaminases, compensated cirrhosis, decompensated cirrhosis, hepatocellular carcinoma, alcoholic hepatitis (AH), or acute-on-chronic liver failure (ACLF); the latter two conditions have a short and severe clinical course with high short-term mortality. This chapter also focuses on the management of ALD, with special focus on living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) in patients with severe alcoholic hepatitis, alcohol-related acute on chronic liver failure and decompensated ALD and their outcomes with regard to survival and post-transplant recidivism.