In many situations in life, bridges must be skewed to connect with existing roads, canals, or additional infrastructure. Skewed bridges exhibit distinct behavioural characteristics rather than straight bridges because of the angled supports. In this study, the effect of skew angle on prestressed trapezoidal box-girder bridge is investigated. The skew angle is varied from 0 to 60°. The finite element based CSiBridge software is used for modelling and analysis of prestressed bridge. The validation has been done with the published results. The values of maximum forces and deflection in bridge deck are evaluated under dead load, prestress load, 3- lane IRC Class-A load. Skewed bridges have lower bending moments and deflections than straight bridges. Furthermore, the effect of skew angle on these reactions is higher under dead load conditions. The equations of forces and deflection ratios of prestressed skewed bridge under different loads using statistical approach are proposed. These equations are helpful for analysing the skewed bridge with the help of straight bridge.