In the current study, coconut oil-based nano-grease doped with 2 wt.% of hexagonal boron nitride (h-BN) and copper oxide (CuO) nanoparticles as additives have been investigated to observe its influence on the tribological properties. CuO and h-BN are used as additives because they possess special characteristics that signify their uses, such as chemically inactive, resistance to oxidation, nontoxicity, high thermal conductivity, environmentally friendly, and exceptional lubricity. The coconut oil-based nano-grease was formulated by adding lithium stearate and was synthesized by sonochemical homogenization technique. In order to perform the tribological analysis, experiments were performed in configurations of ball on discs with a reciprocating test rig at different loading speeds from 10 to 50 N, 2 mm stroke length, and 50 Hz frequency under varying load conditions. Upon comparison with virgin coconut oil grease, the addition of nanoparticles has led to significant reduction in the friction coefficient and wear. On adding h-BN and CuO in coconut oil grease, friction coefficient was reduced by 17% and 28%, respectively. As compared to h-BN, CuO reported a better wear reduction. It was observed that capability of the nanoparticles to create protective film especially by CuO is the main cause of enhanced tribological behaviour. Further analysis by 3D profilometer reported lower roughness values of worn samples doped with the nanoparticles.