The scrotum is a dual-sac of skin and muscle containing the testes, epididymides, blood vessels, and part of the spermatic cord, divided by a septum. The most common problems include development of a mass, torsion, and epididymitis. Clinical presentations often overlap among the various scrotal diseases, leading to frequent misdiagnoses among the cases of testicular tumor, testicular torsion, and epididymitis, especially in young men, and physical examination is often limited due to swelling and pain. With these limitations of clinical evaluation, imaging plays the crucial role in differentiating the scrotal diseases. Ultrasonography (US) is generally recognized as the primary tool for the evaluation of scrotal diseases, while magnetic resonance (MR) imaging can be used when US results are equivocal or suboptimal, or when there is a discrepancy between clinical and US findings.