Urethral abnormalities are most commonly evaluated with conventional radiographic contrast studies including retrograde urethrography (RGU) and voiding cystourethrography (VCU). They are excellent in evaluating luminal abnormalities of the urethra in patients with urethral abnormalities such as trauma, inflammation, stricture, or obstruction. With recent advances in technology, cross-sectional imaging techniques of ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) have been utilized more often because they provide not only direct visualization of urethral abnormalities but also additional information about the periurethral tissues and adjacent organs. This chapter describes the normal anatomy of the urethra in men and women, as well as various urethral abnormalities including traumatic injuries, stricture and inflammation, stones, fistula, diverticulum, and tumors.