This chapter first summarizes the therapy for addiction disorder and elaborates on the progress of medication. First, the difference between dependency and addiction is introduced. The basic principles of the therapy of substance and non-substance addiction are then put forward. It is also pointed out in this chapter that with the progress of the study, the goal of addiction disorder therapy is expected to transfer from reducing relapse and mitigating harm to eliminating and recovering from psychological addiction and effectively treating comorbidities of other mental disorders. This chapter also introduces the progress of psychological addiction elimination technology, especially the “Unconditioned Stimulus Retrieval Extinction Paradigm and Conditioned Stimulus Retrieval Extinction Paradigm” and TPMIH technology. With the development of the times and science, many new technologies are also applied to addiction disorder therapy, such as VR (virtual reality), mobile applications, etc. Finally, it is pointed out that in addiction disorder therapy, comprehensive intervention has become a trend. Concerning the medication for addiction disorders, this chapter also includes the progress and deficiencies of substance and non-substance addiction. In terms of addiction disorder rehabilitation, the foundation of substance addiction is medication, which is, however, limited to non-substance addiction. The key to the recovery of addiction disorder lies in the efficient repair of pathological memories at the implicit memory level that leads to addiction, especially the elimination of psychological craving and the efficient repair of pathological memories that lead to comorbidities. Systematic and precise clinical psychological intervention can achieve this goal in an in-depth and efficient way.