Cam shedding is a kind of shedding form commonly used in modern high speed loom, which has the characteristics of high motion precision and good impact resistance. In this paper, conjugate cam is applied to the shedding mechanism design of rapier loom. By analyzing the principle of cam mechanism, studying the motion characteristics of the follower, calculating the key parameters such as pressure Angle and curvature radius, the conjugate cam shedding mechanism of high-speed rapier loom is designed. In the Matlab environment, the main cam theoretical contour design program was written, the reasonable cam pressure Angle and roller radius were determined, the three-dimensional model of conjugate cam mechanism was established by using SolidWorks, and the Motion law of pendulum rod, two-arm rod and heald frame was verified by the simulation of motion module. At the same time, the conjugate cam and heald frame were analyzed by finite element statics. The simulation results show that the angular displacement, angular velocity and angular acceleration of the swinging rod and the two-arm rod are consistent with the theoretical profile expectation of Matlab, and conform to the motion law of the rapier loom heald frame. In the process of motion of the heald frame, the conjugate cam and the roller can keep continuous contact with each other, which has good motion stability and mechanism performance. It provides strong support for the design innovation and practical application of rapier loom shedding mechanism.