Zinc (Zn)-based biodegradable alloys have emerged as promising candidates for biomedical applications, particularly in temporary implants, orthopedic scaffolds, and cardiovascular stents. Their favorable degradation behavior, biocompatibility, and mechanical properties make them attractive alternatives to conventional implant materials. This chapter provides a comprehensive overview of recent developments related to the composition of different Zn-based biodegradable alloys. It discusses the effect of designed composition on the biocompatibility, degradation rate, and mechanical performance of the developed material. Additionally, it discusses both conventional and advanced manufacturing techniques to fabricate desired Zn-alloy-based implants and parts. This chapter also provides insights into different surface modification techniques and discusses the limitations and challenges associated with widespread clinical adoption of Zn-based biodegradable alloys. Finally, it presents the future research directions for overcoming these challenges.