Developing molecular-scale devices for processing information, i.e., molecular-scale computers, is crucial for creating robotic systems at this scale. In this section, we present a framework for performing computation using molecular-scale components. We base our approach on a Brownian Circuit, which enables asynchronous (clock-free) operations with sufficient computational power. We demonstrate two types of implementations of the Brownian Circuit: asynchronous Cellular Automaton-based and Swarm Agents-based (robot-based) approaches. Both implementations operate in a collective manner. Moreover, each element in the system is simple and uniform, and the interactions among these elements can produce complex operations within the Brownian Circuit.