Site-specific seismic response analysis for Itanagar city is presented in this chapter. Borehole data available from two sites in Itanagar city, with depths varying from 9 to 19.5 m, were used and analyzed for site amplification factors. Based on the SPT N values from the collected soil borehole data, Shear wave velocities (Vs) were calculated using available empirical relationship. Soil sites in Itanagar city were classified based on calculated shear wave velocities as CD and D class types as per NEHRP (2020). The equivalent-linear approach is used to perform one-dimensional ground response studies using DEEPSOIL software. The earthquake time-history data of Sikkim (2011, Mw 6.8), Bhuj (2001, Mw 7.6), Chamoli (1999, Mw 6.6), and Indo-Burma border (1988, Mw 7.2) were used as input motions. The input motions were applied at the bedrock level, which was considered as rigid, with amplification assumed to be unity. The peak ground acceleration (PGA) and time-history plots at the surface level and their variations with depth are presented for the different soil sites in Itanagar city. The amplification factor for each site is presented, and the influence of the earthquake motion on the soil type is also discussed in detail. Based on this study, it is observed that there is an amplification of ground motion, which is about 1.3–4 times at the surface level in comparison to the ground motion at the bedrock level. The response spectra at various sites in the city were compared with the IS 1893–2016 response spectra, with some sites showing higher surface-level values than those specified in IS 1893–2016.