Diabetes mellitus (DM) and its complications pose significant health challenges worldwide. Many therapeutic approaches have been suggested for DM, but none are considered optimal solutions. Regenerative medicine (RM) is a promising branch of medical science that offers new therapeutic modalities for some chronic incurable diseases including DM. RM can be classified into four main categories: cell therapy, tissue engineering, gene therapy, and cell-free therapeutics. Pancreatic islet transplantation is a cell-based therapy for diabetes that predates the introduction of the RM concept. Newer strategies, such as mesenchymal stem cell transplantation, transplantation of islet progenitors or insulin-producing cells, and the application of tissue-engineered biological dressings, are examples of promising regenerative therapies for DM and its complications. This chapter presents some new advancements in the field of diabetes regenerative therapies focusing on cell-based approaches and organoid technologies.