BiopolymersBiopolymers are emerging as green and safer substitutes for man-made materials in drug delivery andImplantable scaffolds implantable devicesImplantable devices in medicine. Their inherent biocompatibility, biodegradability, and lower environmental impact make them particularly valuable for biomedical applicationsBiomedical applications. Over the years, advancements in material science and biomedical engineering have played a major role in shaping drug delivery systemsDrug Delivery Systems (DDS) based on biopolymers for controlled and targeted therapy. Some of the most prominent examples are chitosanChitosan, alginateAlginate, hyaluronic acidPoly (Lactic-Co-Glycolic Acid) (PLGA), poly (lactic-co-glycolic acid) PLGA, and silk fibroin, which have shown immense promise in formulating novel drug carriers, nano-based delivery systems, and tissue engineeringTissue engineering scaffolds. This chapter discusses the broad applications of biopolymersBiopolymers, especially inStimuli-responsive carriers stimuli-responsive and customized drug delivery systems. Both biopolymers blended with nanotechnologyNanotechnology and 3D printing3D-printing methods are explored, with the benefits of more effective therapeutic effects by enhanced bioavailability of the drug, reduced side effects, and increased patient compliance. Regulatory implications, existing limitations, and future prospects for biopolymer-based systems are also discussed with emphasis on novel smart biomaterialsSmart biomaterials and their relevance in the clinical context. With the rising need for patient-friendly and environmentally friendly medical solutions, biopolymersBiopolymers offer a promising route for the creation of next-generation therapeutic platforms. This chapter is intended to present an overview of their functional characteristics, modifiability, and expanding role in contemporary drug delivery and implantable technologies.