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Crosslinking of biopolymers has emerged as a critical strategy to enhance the structural integrity, mechanical strength, and functional performance of biomaterials, making them suitable for diverse clinical applications. BiopolymersBiopolymers, derived from natural sources such as polysaccharidesPolysaccharides, proteinsProteins, and nucleic acids, exhibit tremendous biocompatibility and biodegradabilityBiodegradability, rendering them ideal for biomedical use. However, their inherent limitations, including poor mechanical strength and rapid degradation, necessitate crosslinking to achieve desired physicochemical properties for specific medical applications. This chapter examines various crosslinking techniquesCrosslinking techniques, including physical, chemical, and hybrid methods, used to optimize biopolymer characteristics. The effects of crosslinking on the physicochemical properties of biopolymers, such as mechanical stability, swelling behavior, and degradation profiles, are systematically analyzed. A comprehensive overview of the clinical applications of crosslinked biopolymers is provided, focusing on drug delivery systemsDrug Delivery Systems (DDS), wound healingWound healing, tissue engineeringTissue engineering scaffoldsScaffolds, orthopedicOrthopedic applications implants, and cardiovascular devices. The chapter highlights the role of crosslinking in enabling controlled drug releaseControlled drug release, improving cellular interactions, and enhancing implant longevity. Additionally, emerging smart biopolymer systems that respond to environmental stimuli such as pH, temperature, and enzymes are discussed as promising innovations. Challenges associated with crosslinking, such as cytotoxicity, regulatoryRegulatory challenges issues, and scalability, are addressed. The chapter also explores recent advancements in bioinspired and green crosslinking techniquesCrosslinking techniques aimed at improving biocompatibility and minimize toxic by-products. Overall, this chapter provides valuable insights into the principles of crosslinked biopolymersBiopolymers and their transformative potential in modern healthcare, driving future developments in biomaterials and regenerative medicine.

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Crosslinking Biopolymers and Its Clinical Applications

  • 章节

  • 发表日期：

    2026年

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  • Syed Anees Ahmed,
  • Munkhtuya Tumurkhuu,
  • Guru R. Valicherla,
  • Satyaveni Malasala,
  • Bushra Iqbal,
  • Md Saquib Hasnain,
  • Musarrat Husain Warsi

摘要

Crosslinking of biopolymers has emerged as a critical strategy to enhance the structural integrity, mechanical strength, and functional performance of biomaterials, making them suitable for diverse clinical applications. BiopolymersBiopolymers, derived from natural sources such as polysaccharidesPolysaccharides, proteinsProteins, and nucleic acids, exhibit tremendous biocompatibility and biodegradabilityBiodegradability, rendering them ideal for biomedical use. However, their inherent limitations, including poor mechanical strength and rapid degradation, necessitate crosslinking to achieve desired physicochemical properties for specific medical applications. This chapter examines various crosslinking techniquesCrosslinking techniques, including physical, chemical, and hybrid methods, used to optimize biopolymer characteristics. The effects of crosslinking on the physicochemical properties of biopolymers, such as mechanical stability, swelling behavior, and degradation profiles, are systematically analyzed. A comprehensive overview of the clinical applications of crosslinked biopolymers is provided, focusing on drug delivery systemsDrug Delivery Systems (DDS), wound healingWound healing, tissue engineeringTissue engineering scaffoldsScaffolds, orthopedicOrthopedic applications implants, and cardiovascular devices. The chapter highlights the role of crosslinking in enabling controlled drug releaseControlled drug release, improving cellular interactions, and enhancing implant longevity. Additionally, emerging smart biopolymer systems that respond to environmental stimuli such as pH, temperature, and enzymes are discussed as promising innovations. Challenges associated with crosslinking, such as cytotoxicity, regulatoryRegulatory challenges issues, and scalability, are addressed. The chapter also explores recent advancements in bioinspired and green crosslinking techniquesCrosslinking techniques aimed at improving biocompatibility and minimize toxic by-products. Overall, this chapter provides valuable insights into the principles of crosslinked biopolymersBiopolymers and their transformative potential in modern healthcare, driving future developments in biomaterials and regenerative medicine.