The study aims to convert mixed plastic waste (MPW) originating from railway stations in India into valuable fuels for domestic heating, industrial heating, and automotive sector applications. An innovative thermo-catalytic depolymerization (TCD) technology was employed to produce the fuels. The MPW was subjected to thermo-chemical degradation at an optimized temperature range of 400–450 ℃ for 5–6 hours to obtain liquid pyro-fuel, pyro-char, and flammable pyro-gas. The pyro-fuel properties were analyzed as per the ASTM standards. Notably, the properties of fuel generated from MPW represented comparable results with those of conventional petroleum fuels. The produced pyro-fuels could effectively be used in domestic heating utilities such as air-pressure stoves, domestic wick stoves, and domestic LPG stoves. The industrial gas burner was also operated with the pyro-gas. Finally, the upgraded pyro-fuel was utilized in automotive two-wheeler applications.