Bitumen is a widely utilized binder used in highways and airfield runways, owing to its commendable adhesion characteristics with aggregate. Bitumen comprises of saturates, aromatics, resins, and asphaltenes existing in various forms and proportions depending on temperature conditions, affecting its flow characteristics from viscous to pure elastics condition. Pavement failure, a common characteristic of failing bitumen, must be modified to enhance its properties by polymers like plastomers and elastomers incorporated by process of polymer modifications. These samples of polymer-modified bitumen (PMB) were indicated improved properties such as higher stiffness at high temperature, better moisture resistance, or longer fatigue life. Several other factors influence the properties of PMB such as characteristics of bitumen and polymer, polymer content, and its manufacturing process. This study helps in depicting the optimum binder content in BC Grade 1 mix with PMB 40 reduced by 19.50% when compared with VG30 resulting in economical mix. Also, the TSR and fatigue life have increased by 8% and 15.43% for BC Grade 1 mix with PMB 40 when compared with VG 30 resulting in better moisture susceptibility and increase in service life of pavement. This study has depicted that use of PMB 40 as binder in BC Grade 1 mix ensures the pavement to be durable and reduces burden on virgin aggregates due to its better fatigue and moisture susceptibility characteristics.