According to the requirements of domestic and foreign laws, regulations and standards, human factors engineering needs to be considered in the early design stage of nuclear power plants and iterated throughout the entire life cycle. By introducing advanced human factors engineering concepts, human factors are taken into account in advance during the preliminary design phase of new projects, so as to improve the user experience of products and services, and strive to make the design fit human usage habits to the greatest extent and reduce the probability of human error. Therefore, this paper gives the development of human factors engineering design guidelines for the whole plant during the preliminary design phase of nuclear power plants, the process of human factors integration and design guidance, as well as the establishment and scope of human factors review methods. Through the establishment of the human factors integration system method, the purpose of improving the design is achieved.