With the rapid development of intelligent cockpit technology, automotive ergonomics is undergoing profound changes. The interaction mode centered on mechanical control in traditional driving environments is gradually being replaced by multimodal interaction dominated by intelligent voice, touch, gesture recognition, and emotional perception. The integrated artificial intelligent (AI) assistant, adaptive interface, and augmented reality (AR) technologies in the cabin not only enhance the driver’s operational convenience, but also significantly improve passenger comfort and safety. This paper explores the impact of intelligent cockpits on human-machine-environment (H-M-E) system, human-machine interaction modes, seat design, information visualization, and driving behavior, analyzes its inspiration for future automotive ergonomics design concepts, and looks forward to new trends in human-machine interaction based on cockpit intelligence. And the paper emphasizes that different levels of autonomous driving modes have a significant impact on the ergonomics design and human-machine interaction mode of the intelligent cockpit.