Space stations operate far from ground support, requiring maintenance without system shutdown. The limited storage space within sealed cabins restricts the storage of spare parts and tools, leading to high safety risks and stringent support constraints. To address these challenges, systematic practices of integrated support technology have been developed during the space station’s development and in-orbit operations. This paper summarizes a safety, reliability, and maintainability (SRM) integrated design method focused on ensuring service life, an integrated ground-space spare parts support system, and a lifecycle-oriented in-orbit material management approach. Considering the characteristics of long-term space station missions, a comprehensive support model transitioning from “ensuring lifespan” to “extending lifespan” is proposed.