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Objective. To systematically analyze the molecular features of ADRA2A gene polymorphisms and their clinical associations. Method. By collecting Pubmed, CNKI and other databases, 23 relevant papers were investigated. Result. We mainly explored the regulatory role of polymorphic sites including rs1800544 and rs553668 of ADRA2A gene in exercise disease, neuropsychiatric disease, cardiovascular disease and drug response, and revealed the molecular mechanism that affects noradrenaline metabolism through cAMP signaling pathway. Conclusions. ADRA2A gene polymorphisms can be used as biomarkers for precision diagnosis and treatment of various diseases.

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Advances in the Study of Polymorphisms of ADRA2A Gene Related to Motion Sickness in Human-Machine Environment

  • 会议论文

  • 发表日期：

    2026年

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  • Jingyu Mao,
  • Shuo Li,
  • Jia Liu,
  • Dagui Qin,
  • Shijie Chang,
  • Dawei Tian

摘要

Objective. To systematically analyze the molecular features of ADRA2A gene polymorphisms and their clinical associations. Method. By collecting Pubmed, CNKI and other databases, 23 relevant papers were investigated. Result. We mainly explored the regulatory role of polymorphic sites including rs1800544 and rs553668 of ADRA2A gene in exercise disease, neuropsychiatric disease, cardiovascular disease and drug response, and revealed the molecular mechanism that affects noradrenaline metabolism through cAMP signaling pathway. Conclusions. ADRA2A gene polymorphisms can be used as biomarkers for precision diagnosis and treatment of various diseases.