Due to its hygroscopic nature, wood’s mechanical properties can be highly affected by its moisture content. It is crucial to comprehend how moisture affects wood products, especially the longevity, serviceability and load-bearing capacity. This study aimed to model the fracture behavior of double cantilever beam (DCB) specimens using ABAQUS to investigate how moisture distribution affects the load–displacement (P–δ) response. First, to validate the model, the experimentally measured mean moisture content (MC) was applied in the numerical simulation, and the resulting response was compared with experimental data. Next, it was assumed that the experimental mean MC represents the average of MC of different regions within the DCB; each assigned specific orthotropic material properties based on local moisture content. By appropriately assigning moisture-dependent material properties, the impact of the moisture distribution on its fracture behavior was then examined numerically.