This study explores the potential of 3D Concrete Printing (3DCP) to improve the aesthetic and functional qualities of façade panels through the inspiration of biomimetic design. By incorporating natural patterns, such as shark skin denticles, into a parametric design model, this research presents a strategy for translating natural patterns into designs that can leverage 3DCP technology. The parametric model developed allows for customizing critical design parameters, such as denticle size and cross-sectional overhangs, within limits imposed by 3DCP equipment, allowing users to personalize their façade panels while ensuring the printing quality and the pattern’s geometric integrity. While the study offers a promising approach to enhancing the aesthetics, performance, and customization of the design surface of a façade panel, further research is necessary to investigate material properties and refine the integration between the panel surface and the infill to finalize the panel’s structural integrity. This research opens the way for more customizable and sustainable architectural designs through 3DCP technology.